Do Vitamin D Supplements Reduce Your Risk of Alzheimer’s Disease? (2024)

Studies have linked low vitamin D with a higher risk of Alzheimer’s disease. However, it’s not clear whether vitamin D supplementation lowers Alzheimer’s risk. You can get vitamin D through sun exposure as well as your diet.

Do Vitamin D Supplements Reduce Your Risk of Alzheimer’s Disease? (1)Share on Pinterest

Alzheimer’s disease (AD) is the most common form of dementia in older adults. According to the Alzheimer’s Association, 6 million people in the United States are currently living with AD. This number is expected to increase to almost 13 million by 2050.

There’s currently no cure for AD. Additionally, there’s no surefire way to prevent AD from developing, although certain lifestyle choices may help to reduce your risk.

Some research has suggested that vitamin D supplementation may reduce the risk of AD. Continue reading to discover more.

Learn more about Alzheimer’s disease.

Research done in animals and cells in a laboratory indicates that vitamin D has a neuroprotective effect.

It has been found to decrease amyloid beta production and may also protect against changes in tau protein that may contribute to AD. But it’s not clear whether any aspect of these research results has an effect on humans.

Research has also linked low vitamin D with a higher risk of AD. A 2014 study found that, compared to those with sufficient vitamin D, participants who were deficient in vitamin D had a higher risk of dementia and AD.

Results like these raised the question of whether or not supplementation with vitamin D could reduce the risk of AD. Generally speaking, results have been mixed.

A 2020 review analyzed nine clinical trials of the effects of vitamin D supplements on AD risk. The reviewers didn’t find enough evidence to support the use of vitamin D for preventing AD and note that more research is needed.

A 2023 study explored vitamin D and AD risk. It found that vitamin D exposure was associated with living longer without dementia and 40% lower dementia incidence in general compared to no vitamin D exposure.

The study also highlighted certain groups that may receive the most benefits from vitamin D regarding AD risk. These included:

  • people assigned female at birth
  • people with standard cognition, as opposed to those with mild cognitive impairment (MCI)
  • people who didn’t carry the apolipoprotein E ε4 gene, a known risk factor for AD

The bottom line

Some evidence suggests that vitamin D supplementation may help to lower the risk of AD. However, results of studies looking into the effects of vitamin D on AD development have been mixed.

Additionally, studies have yet to confirm a direct causal link between vitamin D supplementation and prevention of AD. Overall, more research is needed into this topic, including larger, more rigorous clinical trials.

Was this helpful?

While vitamin D has many health benefits, getting too much vitamin D from supplements is potentially harmful. According to the National Institutes of Health (NIH), having too much vitamin D in your blood can lead to:

  • nausea or vomiting
  • reduced appetite
  • excessive urination and thirst
  • dehydration
  • muscle weakness
  • pain
  • kidney stones
  • confusion

Very high levels can cause irregular heart rate, kidney failure, and potentially death. The NIH also notes that most instances of excess vitamin D are in people taking vitamin D supplements.

The amount of daily vitamin D that’s recommended for you depends on your age. The table below shows daily vitamin D recommendations according to the NIH.

NIH vitamin D recommendations

AgeRecommended daily vitamin D in micrograms (mcg) and International units (IU)
Birth to 12 months10 mcg (400 IU)
Ages 1 to 70 years15 mcg (600 IU)
Age 71 and older20 mcg (800 IU)
Pregnant and nursing 15 mcg (600 IU)

Your body naturally produces vitamin D in response to sunlight. While some research suggests 5–30 minutes of sun exposure most days of the week can lead to sufficient vitamin D production, this can vary based on:

  • the season and length of the day
  • whether or not there’s a lot of cloud cover
  • air pollution
  • sunscreen use
  • skin melanin content

Prolonged sun exposure is also linked to the development of skin cancer. As such, it’s also a good idea to enrich your diet with foods that are high in vitamin D.

Some examples of foods that are rich in vitamin D include:

  • certain fish, including:
    • fatty fish like trout, salmon, and mackerel
    • canned tuna
    • herring and canned sardines
  • egg yolks
  • beef liver
  • mushrooms
  • vitamin D-fortified foods, such as:
    • milk
    • soy milk or almond milk
    • certain yogurts
    • orange juice
    • some breakfast cereal products

Is there a link between vitamin D and worsened Alzheimer’s?

One 2022 study of animal models and a human cohort suggested that vitamin D supplementation worsened AD. However, the authors of a 2023 article questioned this study’s methods and interpretation of results.

Results on whether or not vitamin D improves function in dementia have been mixed. Some studies have seen the benefits of vitamin D for MCI and AD. However, a 2022 review didn’t find enough evidence that vitamin D improves function.

What is the best vitamin supplement for Alzheimer’s?

The National Center for Complementary and Integrative Health (NCCIH) notes that while some studies have shown modest effects for some supplements in preventing cognitive decline and dementia, direct evidence is lacking.

The organization does note that the most consistent positive results have been in studies of omega-3 fatty acid supplements.

How much vitamin D is needed to prevent dementia?

A causal link between low vitamin D and dementia hasn’t been proven. However, it’s known that low vitamin D can cause a variety of health problems. As such, it’s always a good rule of thumb to ensure you’re getting sufficient daily vitamin D.

The NIH recommends that most people get 15 mcg (600 IU) of vitamin D each day for general health.

Research has linked low vitamin D with a higher risk of AD. However, the results of studies on whether or not vitamin D supplementation reduces the risk of AD have been mixed. Overall, more research into this topic is needed.

You can get vitamin D by sun exposure and via your diet. Individuals who cannot get enough vitamin D through these routes may need to take a supplement. Always talk with your doctor before adding any new supplements to your diet.

Do Vitamin D Supplements Reduce Your Risk of Alzheimer’s Disease? (2024)

FAQs

Do Vitamin D Supplements Reduce Your Risk of Alzheimer’s Disease? ›

Studies have linked low vitamin D with a higher risk of Alzheimer's disease. However, it's not clear whether vitamin D supplementation lowers Alzheimer's risk. You can get vitamin D through sun exposure as well as your diet.

Should I take vitamin D supplements? ›

A lack of vitamin D can lead to bone deformities such as rickets in children, and bone pain caused by a condition called osteomalacia in adults. Government advice is that everyone should consider taking a daily vitamin D supplement during the autumn and winter.

How much vitamin D3 should I take daily? ›

Taking a multivitamin with vitamin D may help improve bone health. The recommended daily amount of vitamin D is 400 international units (IU) for children up to age 12 months, 600 IU for people ages 1 to 70 years, and 800 IU for people over 70 years.

What is the difference between vitamin D and vitamin D3? ›

There are quite a few differences between vitamin D and vitamin D3, but the main difference between them is that vitamin D is a fat-soluble vitamin that regulates calcium and phosphorous levels in the body, whereas the vitamin D3 is the natural form of vitamin D produced by the body from sunlight.

Can you take too much vitamin D? ›

Yes, getting too much vitamin D can be harmful. Very high levels of vitamin D in your blood (greater than 375 nmol/L or 150 ng/mL) can cause nausea, vomiting, muscle weakness, confusion, pain, loss of appetite, dehydration, excessive urination and thirst, and kidney stones.

What are the disadvantages of taking vitamin D capsules? ›

Some side effects of taking too much vitamin D include weakness, dry mouth, nausea, vomiting, and others. Taking vitamin D for long periods of time in doses higher than 4000 IU (100 mcg) daily is possibly unsafe and may cause very high levels of calcium in the blood.

What happens to your body when you take vitamin D everyday? ›

What happens to your body when you take the recommended amount of vitamin D every day? If you take vitamin D every day, you may experience several benefits , your bones may be stronger, your muscles and nerves may work correctly, and your immune system may get help fighting bacterial or viral infections.

Is it safe to take 5000 IU of vitamin D3 every day? ›

Although 4,000 IU (100 mcg) is set as the maximum amount of vitamin D you can take safely, several studies have shown that taking up to 10,000 IU (250 mcg) daily is not more likely to cause side effects than lower doses ( 48 , 49 ).

Is 2000 IU vitamin D daily too much? ›

The NIH's recommended daily intake for most people is 600 IU (15 mcg). Generally, it's not recommended to exceed the Tolerable Upper Intake Level (UL), which is 4,000 IU (100 mcg) per day. Some experts, such as the Food and Nutrition Board, suggest that even amounts less than the UL can be harmful over time.

Who should not take vitamin D3? ›

Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Is it better to take vitamin D every day or once a week? ›

The recommended amount of vitamin D to take daily for adults aged 19–70 is 15 micrograms (mcg), or 600 IU. You can get vitamin D in food and supplements, and your body naturally makes vitamin D when you're exposed to the sun. Food sources include beef liver, cheese, and fatty fish.

Why do doctors prescribe vitamin D instead of D3? ›

While most people don't need a prescription for vitamin D, your healthcare provider may prescribe a high-dose supplement to take on a short-term basis. They usually prescribe vitamin D2 because it is more widely available and less expensive than vitamin D3.

What cancels out vitamin D? ›

Some factors that may reduce or block its absorption include: Conditions such as celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis. These can all affect the intestines, preventing them from absorbing vitamin D found in food. BMI (body mass index) higher than 30.

What is too much vitamin D for seniors? ›

Some people may need a higher dose, however, including those with a bone health disorder and those with a condition that interferes with the absorption of vitamin D or calcium, says Dr. Manson. Unless your doctor recommends it, avoid taking more than 4,000 IU per day, which is considered the safe upper limit.

Can you stop taking vitamin D3 suddenly? ›

Ideally it's best to quit gradually in order to give your body a chance to adjust. You're least likely to struggle through the withdrawal process if you take several weeks to decrease how much you take.

What happens if I take vitamin D without needing it? ›

In addition, taking a supplement that contains too much vitamin D can be toxic in rare cases. It can lead to hypercalcemia, a condition in which too much calcium builds up in the blood, potentially forming deposits in the arteries or soft tissues. It may also predispose people to painful kidney stones.

Is there anyone who shouldn't take vitamin D? ›

have problems with your kidneys, such as kidney failure, or you've ever had kidney stones. have hypervitaminosis D – high levels of vitamin D in your blood. have a rare condition called sarcoidosis. have calcification – high levels of calcium in your body tissues or organs.

References

Top Articles
Latest Posts
Article information

Author: Lakeisha Bayer VM

Last Updated:

Views: 6529

Rating: 4.9 / 5 (49 voted)

Reviews: 88% of readers found this page helpful

Author information

Name: Lakeisha Bayer VM

Birthday: 1997-10-17

Address: Suite 835 34136 Adrian Mountains, Floydton, UT 81036

Phone: +3571527672278

Job: Manufacturing Agent

Hobby: Skimboarding, Photography, Roller skating, Knife making, Paintball, Embroidery, Gunsmithing

Introduction: My name is Lakeisha Bayer VM, I am a brainy, kind, enchanting, healthy, lovely, clean, witty person who loves writing and wants to share my knowledge and understanding with you.